In this video collection, authors of findings published in The Journal of Clinical Investigation present personally guided tours of their results. The journal accepts video submissions from authors of recently accepted manuscripts. Instructions can be found on the Author's Take Guidelines page.
In this episode, Leonardo Riella presents his manuscript detailing how a humanized mutein IL-2 selectively expands and boosts the function of mouse, non-human primate and human regulatory T cells, prolonging allograft survival.
In this episode, Tammy Kielian, Kevin Garvin, Christopher Horn, and Prabhakar Arumugam describe how their study demonstrates the importance of a glycolysis/HIF1a axis in promoting G-MDSC anti-inflammatory activity and biofilm persistence during PJI.
In this episode, Jayme Locke and Maggie Jones-Carr explain the histologic outcomes of a series of brain-dead human recipients of a porcine kidney xenotransplant using exclusively FDA-approved medications, with and without anti-C5 monoclonal antibody.
In this episode, Shashwat Tripathi and Hinda Najem discuss how, using scRNA-seq, their analysis shows that CAFs, specifically the immune modulatory subtype, are increased in frequency as a function of glioma grade. Notably, collagen is a key ligand for the immune checkpoint LAIR-1. The study also characterizes which collagens are present in gliomas and their anatomical locations within the tumor microenvironment that can serve as a reference for the scientific community.
In this episode, Laszlo Farkas explains that the results of this study indicate that reduced endothelial expression of endolysosomal RAB7 causes dysregulation of autophagy, mitochondrial dysfunction and endothelial senescence, and induces spontaneous PH.